Cancer-miRNA Regulatory Network

Compendium of miRNA Target Genes

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END Ovarian Hendrix Cluster Number 58 (84 genes) This page contains all miRNA mediated regulation and functional enrichment for END Ovarian Hendrix cluster number 58. Information about ovarian cancer can be found on Wikipedia, and further information about the "END Ovarian Hendrix" dataset can be found in Hendrix et al., 2006. Inferred miRNA Mediated Regulation Weeder-miRvestigator PITA TargetScan hsa-mir-621 zzz999 zzz999 Gene Ontology Enrichment GO ID GO Term Annotated Genes in Cluster GO:0001775 cell activation 18 GO:0002252 immune effector process 10 GO:0002253 activation of immune response 11 GO:0002376 immune system process 38 GO:0002429 immune response-activating cell surface receptor signaling pathway 11 GO:0002520 immune system development 11 GO:0002521 leukocyte differentiation 9 GO:0002682 regulation of immune system process 21 GO:0002684 positive regulation of immune system process 17 GO:0002694 regulation of leukocyte activation 14 GO:0002696 positive regulation of leukocyte activation 10 GO:0002757 immune response-activating signal transduction 11 GO:0002764 immune response-regulating signaling pathway 11 GO:0002768 immune response-regulating cell surface receptor signaling pathway 11 GO:0006873 cellular ion homeostasis 10 GO:0006874 cellular calcium ion homeostasis 9 GO:0006875 cellular metal ion homeostasis 10 GO:0006935 chemotaxis 11 GO:0006950 response to stress 31 GO:0006952 defense response 20 GO:0006954 inflammatory response 10 GO:0006955 immune response 30 GO:0006968 cellular defense response 5 GO:0007165 signal transduction 39 GO:0007166 cell surface receptor linked signaling pathway 27 GO:0007204 elevation of cytosolic calcium ion concentration 7 GO:0009611 response to wounding 18 GO:0030003 cellular cation homeostasis 10 GO:0030097 hemopoiesis 9 GO:0030098 lymphocyte differentiation 8 GO:0030217 T cell differentiation 7 GO:0031294 lymphocyte costimulation 6 GO:0031295 T cell costimulation 6 GO:0040011 locomotion 20 GO:0042100 B cell proliferation 4 GO:0042110 T cell activation 12 GO:0042330 taxis 11 GO:0045321 leukocyte activation 17 GO:0045580 regulation of T cell differentiation 4 GO:0046649 lymphocyte activation 16 GO:0048518 positive regulation of biological process 29 GO:0048534 hemopoietic or lymphoid organ development 11 GO:0048535 lymph node development 3 GO:0048583 regulation of response to stimulus 23 GO:0048584 positive regulation of response to stimulus 15 GO:0050776 regulation of immune response 17 GO:0050778 positive regulation of immune response 13 GO:0050789 regulation of biological process 57 GO:0050794 regulation of cellular process 54 GO:0050851 antigen receptor-mediated signaling pathway 11 GO:0050852 T cell receptor signaling pathway 7 GO:0050853 B cell receptor signaling pathway 3 GO:0050857 positive regulation of antigen receptor-mediated signaling pathway 2 GO:0050862 positive regulation of T cell receptor signaling pathway 2 GO:0050863 regulation of T cell activation 12 GO:0050865 regulation of cell activation 14 GO:0050867 positive regulation of cell activation 10 GO:0050870 positive regulation of T cell activation 8 GO:0050896 response to stimulus 57 GO:0050900 leukocyte migration 8 GO:0051249 regulation of lymphocyte activation 14 GO:0051251 positive regulation of lymphocyte activation 9 GO:0051480 cytosolic calcium ion homeostasis 7 GO:0055065 metal ion homeostasis 10 GO:0055074 calcium ion homeostasis 9 GO:0055080 cation homeostasis 10 GO:0055082 cellular chemical homeostasis 10 GO:0065007 biological regulation 63 Overlap Between miRNA Target Genes and Enriched Gene Ontology Annotations miRNA Method GO ID GO Term Overlap GO Annotated Genes Cluster Size miRNA Targets Genes P-Value hsa-mir-621 miRvestigator GO:0001775 cell activation 7 18 84 39 0.6746562 hsa-mir-621 miRvestigator GO:0002252 immune effector process 6 10 84 39 0.1047929 hsa-mir-621 miRvestigator GO:0002253 activation of immune response 4 11 84 39 0.6503923 hsa-mir-621 miRvestigator GO:0002376 immune system process 17 38 84 39 0.5248044 hsa-mir-621 miRvestigator GO:0002429 immune response-activating cell surface receptor signaling pathway 4 11 84 39 0.6503923 hsa-mir-621 miRvestigator GO:0002520 immune system development 3 11 84 39 0.8513444 hsa-mir-621 miRvestigator GO:0002521 leukocyte differentiation 2 9 84 39 0.8834155 hsa-mir-621 miRvestigator GO:0002682 regulation of immune system process 7 21 84 39 0.872477 hsa-mir-621 miRvestigator GO:0002684 positive regulation of immune system process 5 17 84 39 0.904611 hsa-mir-621 miRvestigator GO:0002694 regulation of leukocyte activation 4 14 84 39 0.8804287 hsa-mir-621 miRvestigator GO:0002696 positive regulation of leukocyte activation 2 10 84 39 0.9284775 hsa-mir-621 miRvestigator GO:0002757 immune response-activating signal transduction 4 11 84 39 0.6503923 hsa-mir-621 miRvestigator GO:0002764 immune response-regulating signaling pathway 4 11 84 39 0.6503923 hsa-mir-621 miRvestigator GO:0002768 immune response-regulating cell surface receptor signaling pathway 4 11 84 39 0.6503923 hsa-mir-621 miRvestigator GO:0006873 cellular ion homeostasis 5 10 84 39 0.2808559 hsa-mir-621 miRvestigator GO:0006874 cellular calcium ion homeostasis 4 9 84 39 0.4082427 hsa-mir-621 miRvestigator GO:0006875 cellular metal ion homeostasis 5 10 84 39 0.2808559 hsa-mir-621 miRvestigator GO:0006935 chemotaxis 7 11 84 39 0.05992743 hsa-mir-621 miRvestigator GO:0006950 response to stress 17 31 84 39 0.07941969 hsa-mir-621 miRvestigator GO:0006952 defense response 12 20 84 39 0.0492344 hsa-mir-621 miRvestigator GO:0006954 inflammatory response 7 10 84 39 0.02574421 hsa-mir-621 miRvestigator GO:0006955 immune response 13 30 84 39 0.5768618 hsa-mir-621 miRvestigator GO:0006968 cellular defense response 3 5 84 39 0.1385414 hsa-mir-621 miRvestigator GO:0007165 signal transduction 18 39 84 39 0.4315155 hsa-mir-621 miRvestigator GO:0007166 cell surface receptor linked signaling pathway 11 27 84 39 0.6854315 hsa-mir-621 miRvestigator GO:0007204 elevation of cytosolic calcium ion concentration 3 7 84 39 0.4193391 hsa-mir-621 miRvestigator GO:0009611 response to wounding 11 18 84 39 0.04671134 hsa-mir-621 miRvestigator GO:0030003 cellular cation homeostasis 5 10 84 39 0.2808559 hsa-mir-621 miRvestigator GO:0030097 hemopoiesis 2 9 84 39 0.8834155 hsa-mir-621 miRvestigator GO:0030098 lymphocyte differentiation 2 8 84 39 0.8160151 hsa-mir-621 miRvestigator GO:0030217 T cell differentiation 2 7 84 39 0.7199695 hsa-mir-621 miRvestigator GO:0031294 lymphocyte costimulation 2 6 84 39 0.5911279 hsa-mir-621 miRvestigator GO:0031295 T cell costimulation 2 6 84 39 0.5911279 hsa-mir-621 miRvestigator GO:0040011 locomotion 11 20 84 39 0.1277539 hsa-mir-621 miRvestigator GO:0042100 B cell proliferation 0 4 84 39 0.9227806 hsa-mir-621 miRvestigator GO:0042110 T cell activation 4 12 84 39 0.7467392 hsa-mir-621 miRvestigator GO:0042330 taxis 7 11 84 39 0.05992743 hsa-mir-621 miRvestigator GO:0045321 leukocyte activation 6 17 84 39 0.774985 hsa-mir-621 miRvestigator GO:0045580 regulation of T cell differentiation 1 4 84 39 0.6359655 hsa-mir-621 miRvestigator GO:0046649 lymphocyte activation 5 16 84 39 0.8588606 hsa-mir-621 miRvestigator GO:0048518 positive regulation of biological process 12 29 84 39 0.6706634 hsa-mir-621 miRvestigator GO:0048534 hemopoietic or lymphoid organ development 3 11 84 39 0.8513444 hsa-mir-621 miRvestigator GO:0048535 lymph node development 1 3 84 39 0.4458671 hsa-mir-621 miRvestigator GO:0048583 regulation of response to stimulus 12 23 84 39 0.1857411 hsa-mir-621 miRvestigator GO:0048584 positive regulation of response to stimulus 7 15 84 39 0.3786893 hsa-mir-621 miRvestigator GO:0050776 regulation of immune response 7 17 84 39 0.582927 hsa-mir-621 miRvestigator GO:0050778 positive regulation of immune response 5 13 84 39 0.6246998 hsa-mir-621 miRvestigator GO:0050789 regulation of biological process 23 57 84 39 0.9175294 hsa-mir-621 miRvestigator GO:0050794 regulation of cellular process 22 54 84 39 0.8797991 hsa-mir-621 miRvestigator GO:0050851 antigen receptor-mediated signaling pathway 4 11 84 39 0.6503923 hsa-mir-621 miRvestigator GO:0050852 T cell receptor signaling pathway 4 7 84 39 0.1616558 hsa-mir-621 miRvestigator GO:0050853 B cell receptor signaling pathway 0 3 84 39 0.8510768 hsa-mir-621 miRvestigator GO:0050857 positive regulation of antigen receptor-mediated signaling pathway 0 2 84 39 0.7160069 hsa-mir-621 miRvestigator GO:0050862 positive regulation of T cell receptor signaling pathway 0 2 84 39 0.7160069 hsa-mir-621 miRvestigator GO:0050863 regulation of T cell activation 4 12 84 39 0.7467392 hsa-mir-621 miRvestigator GO:0050865 regulation of cell activation 4 14 84 39 0.8804287 hsa-mir-621 miRvestigator GO:0050867 positive regulation of cell activation 2 10 84 39 0.9284775 hsa-mir-621 miRvestigator GO:0050870 positive regulation of T cell activation 2 8 84 39 0.8160151 hsa-mir-621 miRvestigator GO:0050896 response to stimulus 27 57 84 39 0.3145685 hsa-mir-621 miRvestigator GO:0050900 leukocyte migration 4 8 84 39 0.2787846 hsa-mir-621 miRvestigator GO:0051249 regulation of lymphocyte activation 4 14 84 39 0.8804287 hsa-mir-621 miRvestigator GO:0051251 positive regulation of lymphocyte activation 2 9 84 39 0.8834155 hsa-mir-621 miRvestigator GO:0051480 cytosolic calcium ion homeostasis 3 7 84 39 0.4193391 hsa-mir-621 miRvestigator GO:0055065 metal ion homeostasis 5 10 84 39 0.2808559 hsa-mir-621 miRvestigator GO:0055074 calcium ion homeostasis 4 9 84 39 0.4082427 hsa-mir-621 miRvestigator GO:0055080 cation homeostasis 5 10 84 39 0.2808559 hsa-mir-621 miRvestigator GO:0055082 cellular chemical homeostasis 5 10 84 39 0.2808559 hsa-mir-621 miRvestigator GO:0065007 biological regulation 27 63 84 39 0.8117207

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